Osteoarthritis- a systematic review of long-term safety implications for osteoarthritis of the knee – PMC

There is no cure for knee osteoarthritis (KOA) and typically patients live approximately 30-years with the disease. Most common medical treatments result in short-term palliation of symptoms with little consideration of long-term risk.
— Read on www.ncbi.nlm.nih.gov/pmc/articles/PMC6454763/